In the intricate world of human health, where genetics and environment blend to influence our well-being, “methylation” is a term that’s gaining more attention. Methylation is a biochemical process in the body responsible for vital functions such as DNA repair, detoxification, and neurotransmitter regulation. When this system is out of balance, we often see two major concerns—under methylation and over methylation. Today, we’ll explore what over methylation is, what causes it, and how we can bring the body back into balance.
What is Over Methylation?
At its core, methylation is the body’s way of adding “methyl groups” (one carbon and three hydrogen atoms) to various molecules to regulate gene expression and neurotransmitter function. Some people, however, experience an overabundance of these methyl groups, leading to a phenomenon called over methylation. This condition, though lesser known, may impact up to 10% of the population.
Individuals who experience over methylation often struggle with a cluster of symptoms such as high anxiety, difficulty sleeping (insomnia), and a sense of overstimulation. These patients may also find that taking certain vitamins, particularly methylated B vitamins, exacerbates their symptoms. Others report adverse reactions to SSRIs (Selective Serotonin Reuptake Inhibitors), which can lead them on a frustrating journey from doctor to doctor, searching for answers.
Over methylation doesn’t just present as a series of symptoms—it has a distinct profile. Patients may feel a persistent sense of unease or overstimulation, find it hard to relax, or notice they are sensitive to certain medications. A key indicator is the relief they find in antihistamines, which can calm down an overactive system. With proper diagnosis, there is hope for relief, often through personalized nutrition, detoxification, and lifestyle adjustments.
Common Symptoms of Over Methylation
The symptoms of over methylation can be subtle at first but often evolve into significant health concerns. Here are the most common signs:
How is Over Methylation Diagnosed?
Understanding whether you’re dealing with over methylation is essential in finding the right treatment. There are several diagnostic tools that can help:
- Dutch Urine Test: This test looks at the methylation pathway by assessing neurotransmitter metabolites. If results indicate over methylation and the patient fits the clinical profile, the treatment approach shifts accordingly.
- Homocysteine Levels: Elevated homocysteine levels can be a marker for abnormal methylation, including over methylation.
- Whole Blood Histamine Test: This test is another key indicator. People with over methylation often show low levels of histamine, which gives clues to how the body is managing its methylation pathways.
Treatment Options for Over Methylation
Treating over methylation is about restoring balance, particularly within the nervous system. The goal is to reduce the symptoms of anxiety, calm the body, and optimize neurotransmitter function. Below are some of the most effective nutritional and lifestyle interventions:
- Niacinamide (B3): Known to “use up” excess methyl groups, niacinamide helps bring the system back into balance, calming anxiety and supporting better sleep.
- Vitamin B6 (Pyridoxine): This crucial vitamin supports the production of neurotransmitters like serotonin and GABA, which help regulate mood and calm anxiety.
- Magnesium: Often referred to as nature’s “calm-down” mineral, magnesium is essential for reducing anxiety, calming the nervous system, and promoting restful sleep.
- Zinc: Over methylators often have high levels of copper, which can worsen anxiety. Zinc helps balance copper levels, supporting neurotransmitter regulation and reducing overstimulation.
- Vitamin B12 (Hydroxycobalamin): This non-methylated form of B12 is key in supporting methylation without further aggravating over methylation symptoms.
- Folinic Acid or Folic Acid: Unlike methylfolate, these forms of folate are less likely to overstimulate the methylation pathway, making them more suitable for over methylators.
- Taurine and Glycine: These calming amino acids help regulate excitatory neurotransmitters, promoting relaxation and better sleep quality.
While these nutrients can offer significant relief, it’s just as important to avoid supplements that may increase methylation further. Methylated B vitamins, SAMe, choline, and betaine (TMG) are examples of supplements that may exacerbate symptoms for over methylators.
Over Methylation and MTHFR Mutation: What’s the Connection?
The MTHFR gene mutation is known for its role in under methylation, but individuals with this genetic variation can also experience over methylation, especially if they are supplementing with high doses of methylated nutrients. Several factors influence this paradox:
- Excessive Supplementation: Taking large amounts of methyl donors like methylfolate or methylcobalamin can overwhelm the methylation pathways, even in those with MTHFR mutations.
- Other Genetic Variants: Beyond MTHFR, other genes related to methylation (e.g., COMT or MAO) can impact how methyl groups are processed in the body.
- Environmental and Lifestyle Factors: Stress, poor diet, or toxin exposure can further complicate the methylation balance, pushing an individual toward over-methylation despite genetic predispositions.
Environmental Factors Contributing to Over Methylation
Over methylation doesn’t solely arise from genetics. Several environmental factors can also contribute:
Finding the Right Balance
Over methylation can be frustrating, but with a thoughtful approach to diagnosis and treatment, it’s possible to regain balance and improve well-being. By focusing on non-methylating nutrients, avoiding overstimulation, and addressing environmental and lifestyle factors, individuals with over methylation can calm their systems and restore a sense of normalcy.
As always, it’s crucial to work with a healthcare professional to evaluate your symptoms and create a personalized plan that supports healthy methylation and overall health.
